PrEP remains underutilized, particularly among communities with the greatest unmet need for HIV prevention.

While PrEP use has continued to increase nationally, the latest data show that progress may be slowing and that major disparities persist across race/ethnicity, age, sex, geography, socioeconomic status, and access to care. These gaps underscore the need to expand PrEP awareness, access, and uptake among all people who can benefit.

Barriers to PrEP in the U.S. include limited awareness among providers and individuals who may need or want PrEP, stigma and discrimination, limited availability of PrEP providers, medical mistrust, access to affordable health insurance, affordability of ancillary labs and clinical services associated with PrEP use, and social determinants of health such as poverty, housing instability, systemic racism, homophobia, and transphobia.